Nanduri LS, Baanstra M, Faber H, Rocchi C, Zwart E, de Haan G, van Os R, Coppes RP Stem Cell Reports 2014 Dec;3(6):957-64 PMID: 25448065 Abstract Hyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG) stem cell therapy
Tracing Dynamics and Clonal Heterogeneity of Cbx7-Induced Leukemic Stem Cells by Cellular Barcoding
Klauke K, Broekhuis MJ, Weersing E, Dethmers-Ausema A, Ritsema M, González MV, Zwart E, Bystrykh LV, de Haan G Stem Cell Reports 2014 Nov; PMID: 25434821 Abstract Accurate monitoring of tumor dynamics and leukemic stem cell (LSC) heterogeneity is important
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms
Prick J, de Haan G, Green AR, Kent DG Exp. Hematol. 2014 Oct;42(10):841-851 PMID: 25201757 Abstract Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation. Hematopoietic
MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis
Wojtowicz EE, Walasek MA, Broekhuis MJ, Weersing E, Ritsema M, Ausema A, Bystrykh LV, de Haan G Exp. Hematol. 2014 Oct;42(10):909-918.e1 PMID: 25092555 Abstract MicroRNAs (miRNAs) are crucial for proper functioning of hematopoietic stem and progenitor cells (HSPCs). Members of
CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells
Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M Mol. Ther. 2014 Sep; PMID: 25189742 Abstract Gene therapy for
Priming of microglia in a DNA-repair deficient model of accelerated aging
Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW
microRNAs in hematopoiesis
Lazare SS, Wojtowicz EE, Bystrykh LV, de Haan G Exp. Cell Res. 2014 Sep;329(2):234-238 PMID: 25192911 Abstract miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood
Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency
de Kruijf EJ, Alkemade GM, van Os R, Fibbe WE, van Pel M Int. J. Hematol. 2014 Jun;99(6):714-20 PMID: 24752699 Abstract Granulocyte-colony-stimulating factor (G-CSF)-induced hematopoietic stem and progenitor cell (HSPC) mobilization is associated with the release of neutrophil-derived proteases. Previously,
No monkeying around: clonal tracking of stem cells and progenitors in the macaque
Dykstra B, Bystrykh LV Cell Stem Cell 2014 Apr;14(4):419-20 PMID: 24702990 Abstract Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014)
Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines
Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T, de Haan G, Bystrykh LV J. Exp. Med. 2014 Mar;211(3):487-97 PMID: 24567446 Abstract Hematopoietic stem cells (HSCs) are able to migrate through the blood stream