Tracing Dynamics and Clonal Heterogeneity of Cbx7-Induced Leukemic Stem Cells by Cellular Barcoding

Klauke K, Broekhuis MJ, Weersing E, Dethmers-Ausema A, Ritsema M, González MV, Zwart E, Bystrykh LV, de Haan G Stem Cell Reports 2014 Nov; PMID: 25434821 Abstract Accurate monitoring of tumor dynamics and leukemic stem cell (LSC) heterogeneity is important

MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis

Wojtowicz EE, Walasek MA, Broekhuis MJ, Weersing E, Ritsema M, Ausema A, Bystrykh LV, de Haan G Exp. Hematol. 2014 Oct;42(10):909-918.e1 PMID: 25092555 Abstract MicroRNAs (miRNAs) are crucial for proper functioning of hematopoietic stem and progenitor cells (HSPCs). Members of

CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells

Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M Mol. Ther. 2014 Sep; PMID: 25189742 Abstract Gene therapy for

Priming of microglia in a DNA-repair deficient model of accelerated aging

Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW

Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency

de Kruijf EJ, Alkemade GM, van Os R, Fibbe WE, van Pel M Int. J. Hematol. 2014 Jun;99(6):714-20 PMID: 24752699 Abstract Granulocyte-colony-stimulating factor (G-CSF)-induced hematopoietic stem and progenitor cell (HSPC) mobilization is associated with the release of neutrophil-derived proteases. Previously,

Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines

Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T, de Haan G, Bystrykh LV J. Exp. Med. 2014 Mar;211(3):487-97 PMID: 24567446 Abstract Hematopoietic stem cells (HSCs) are able to migrate through the blood stream