Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP Clin. Cancer Res. 2008 Dec;14(23):7741-50 PMID: 19047101 Abstract PURPOSE: During radiotherapy for head and neck cancer, co-irradiation (IR) of salivary glands results in acute and often lifelong
Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool
Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP Stem Cells 2008 Oct;26(10):2595-601 PMID: 18669914 Abstract Irradiation of salivary glands during radiotherapy treatment of patients with head and neck cancer evokes persistent hyposalivation. This results from
Genetical genomics: spotlight on QTL hotspots
Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de Haan G, Su AI, Jansen RC PLoS Genet. 2008 Oct;4(10):e1000232 PMID: 18949031 Abstract
Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny
Gerrits A, Dykstra B, Otten M, Bystrykh L, de Haan G Immunogenetics 2008 Aug;60(8):411-22 PMID: 18560825 Abstract Stem cells are unique in that they possess both the capacity to self-renew and thereby maintain their original pool as well as the
Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1
Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ Blood 2008 Mar;111(5):2621-30 PMID: 18156489 Abstract The polycomb group (PcG) gene BMI1 has been identified as one of the key epigenetic regulators of cell fates during different stages of
Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia
Kruit JK, Drayer AL, Bloks VW, Blom N, Olthof SG, Sauer PJ, de Haan G, Kema IP, Vellenga E, Kuipers F J. Biol. Chem. 2008 Mar;283(10):6281-7 PMID: 18156627 Abstract Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error
In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C
van Os RP, Dethmers-Ausema B, de Haan G Methods Mol. Biol. 2008;430:143-57 PMID: 18370297 Abstract Various assays exist that measure the function of hematopoietic stemcells (HSCs). In this chapter, in vitro assays are described that measure the frequency of progenitors
Rescue of salivary gland function after stem cell transplantation in irradiated glands
Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, Visser WH, Kampinga HH, de Haan G, Coppes RP PLoS ONE 2008;3(4):e2063 PMID: 18446241 Abstract Head and neck cancer is the fifth most common malignancy and accounts for
Mobilization of hematopoietic stem and progenitor cells in mice
Robinson SN, van Os RP Methods Mol. Biol. 2008;430:31-53 PMID: 18370290 Abstract Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between
Hematopoietic stem cell aging and self-renewal
Dykstra B, de Haan G Cell Tissue Res. 2008 Jan;331(1):91-101 PMID: 18008087 Abstract A functional decline of the immune system occurs during organismal aging that is attributable, in large part, to changes in the hematopoietic stem cell (HSC) compartment. In