Lazare SS, Wojtowicz EE, Bystrykh LV, de Haan G

Exp. Cell Res. 2014 Sep;329(2):234-238

PMID: 25192911

Abstract

miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.

microRNAs in hematopoiesis
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