Lazare S, Ausema A, Reijne AC, van Dijk G, van Os R, de Haan G
Exp. Hematol. 2017 Jun;
Hematopoietic stem cells (HSC) undergo a profound functional decline during normal aging. As caloric or dietary restriction has been shown to delay multiple aspects of the aging process in many species, we here decided to explore the consequences of lifelong caloric restriction or, reversely, lifelong excess caloric intake for HSC numbers and function. Although caloric restriction prevented age-dependent increase in bone marrow cellularity, caloric restriction was not able to prevent functional decline of aged long-term hematopoietic stem cell functioning. In addition, a lifelong high fat diet did not affect stem cell functioning either. We conclude that lifelong caloric interventions fail to prevent or induce loss of age-associated hematopoietic stem cell functioning.