Alberts R, Terpstra P, Bystrykh LV, de Haan G, Jansen RC
Genetics 2005 Nov;171(3):1437-9
Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating “true” differential mRNA expression from “ghost” effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.