Publications

2013:

Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol. 2013 Mar 17. [Epub ahead of print] PMID: 23502315

2012:

Radulović V, de Haan G, Klauke K. Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms. Leukemia. Epub 2012 Dec 21. PMID: 23257781

Walasek MA, Bystrykh LV, Olthof S, de Haan G, van Os R. Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function. Exp Hematol. 2012 Sep 15. PMID: 22989761

Walasek MA, van Os R, de Haan G. Hematopoietic stem cell expansion: challenges and opportunities. Ann N Y Acad Sci. 2012 Aug. PMID: 22901265

Bystrykh LV, Verovskaya E, Zwart E, Broekhuis M, de Haan G. Counting stem cells: methodological constraints. Nat Methods. 2012 May 30. PMID: 22669654

Bystrykh LV. Generalized DNA Barcode Design Based on Hamming Codes. PLoS ONE. 2012 May 17. PMID: 22615825

Walasek MA, Bystrykh LV, van den Boom V, Olthof S, Ausema A, Ritsema M, Huls G, de Haan G, van Os R. The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation. Blood. 2012 Feb 10. PMID: 22327222

Gerrits A, Walasek MA, Olthof S, Weersing E, Ritsema M, Zwart E, van Os R, Bystrykh LV, d de Haan G. Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells. Blood. 2012 Jan 12. PMID: 22123844

2011:

Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med. 2011 Dec 19. PMID: 22110168

Woolthuis CM, de Haan G, Huls G. Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects? Curr Opin Immunol. 2011 Aug;23(4):512-7. Epub 2011 Jun 12. Review. PMID: 21664115

Nanduri LS, Maimets M, Pringle SA, van der Zwaag M, van Os RP, Coppes RP. Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother Oncol. 2011 Jun;99(3):367-72. Epub 2011 Jun 28. PMID: 21719134

Verovskaya EV, de Haan G. The power of diversity: hematopoietic stem cell heterogeneity and its clinical relevance. EHA Education Book. June 2011. ISSN 1872-5503

Klauke K, de Haan G. Polycomb group proteins in hematopoietic stem cell aging and malignancies. Int J Hematol. 2011 Jul;94(1):11-23. Epub 2011 Apr 27. PMID: 21523335

Pringle S, Nanduri LS, van der Zwaag M, van Os R, Coppes RP. Isolation of mouse salivary gland stem cells. J Vis Exp. 2011 Feb 8;(48). pii: 2484. doi: 10.3791/2484. PMID: 21339725

2010:

Rizo A, Horton SJ, Olthof S, Dontje B, Ausema A, van Os R, van den Boom V, Vellenga E, de Haan G, and Schuringa JJ. BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells. Blood published 19 August 2010, 10.1182/blood-2010-02-270660 PMID: 20724541

Kooistra SM, van den Boom V, Thummer RP, Johannes F, Wardenaar R, Tesson BM, Veenhoff LM, Fusetti F, O’Neill LP, Turner BM, De Haan G, Eggen BJ. UTF1 Regulates ES Cell Chromatin Organization and Gene Expression. Stem Cells. 2010 Aug 16. PMID: 20715181

Van Os R, Ausema A, Dontje B, van Riezen M, van Dam G, de Haan G. Engraftment of syngeneic bone marrow is not more efficient after intrafemoral transplantation than following traditional intravenous administration. Exp Hematol. Volume 38, Issue 11, Pages 1115-1123 (November 2010). PMID: 20643182

De Ridder J, Gerrits A, Bot J, De Haan G, Reinders M, Wessels L. Inferring combinatorial association logic networks in multimodal genome-wide screens. Bioinformatics. 2010 Jun 15;26(12):i149-57. PMID: 20529900

Aparicio-Vergara M, Shiri-Sverdlov R, de Haan G, Hofker MH. Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases. Atherosclerosis. 2010 Jun 1. PMID: 20576267

Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, Broekhuis MJ, de Haan G, Bystrykh LV. Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood. 2010 Apr 1;115(13):2610-8. Epub 2010 Jan 21. PMID: 20093403

2009:

Gerrits A, Li Y, Tesson BM, Bystrykh LV, Weersing E, Ausema A, Dontje B, Wang X, Breitling R, Jansen RC, de Haan G. Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genet. 2009 Oct;5(10):e1000692. Epub 2009 Oct 16. PMID: 19834560

Feng J, van der Zwaag M, Stokman MA, van Os R, Coppes RP. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiother Oncol. 2009 Sep;92(3):466-71. Epub 2009 Jul 20. PMID: 19625095

Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ. Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. Blood. 2009 Aug 20;114(8):1498-505. Epub 2009 Jun 25. PMID: 19556423

Van Os R, de Haan G, Dykstra BJ. Hematopoietic stem cell quiescence: yet another role for p53. Cell Stem Cell. 2009 Jan 9;4(1):7-8. PMID: 19128788

2008:

Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation. Clin Cancer Res. 2008 Dec 1;14(23):7741-50. PMID: 19047101

Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de Haan G, Su AI, Jansen RC. Genetical genomics: spotlight on QTL hotspots. PLoS Genet. 2008 Oct;4(10):e1000232. Epub 2008 Oct 24. No abstract available. PMID: 18949031

Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool. Stem Cells. 2008 Oct;26(10):2595-601. Epub 2008 Jul 31. PMID: 18669914

Gerrits A, Dykstra B, Otten M, Bystrykh L, de Haan G. Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny. Immunogenetics. 2008 Aug;60(8):411-22. Epub 2008 Jun 17. Review. PMID: 18560825

Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, Visser WH, Kampinga HH, de Haan G, Coppes RP. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One. 2008 Apr 30;3(4):e2063. PMID: 18446241

Van Os RP, Dethmers-Ausema B, de Haan G. In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C. Methods Mol Biol. 2008;430:143-57. PMID: 18370297

Kruit JK, Drayer AL, Bloks VW, Blom N, Olthof SG, Sauer PJ, de Haan G, Kema IP, Vellenga E, Kuipers F. Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia. J Biol Chem. 2008 Mar 7;283(10):6281-7. Epub 2007 Dec 21. PMID: 18156627

Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ. Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1. Blood. 2008 Mar 1;111(5):2621-30. Epub 2007 Dec 21. PMID: 18156489

Dykstra B, de Haan G. Hematopoietic stem cell aging and self-renewal. Cell Tissue Res. 2008 Jan;331(1):91-101. Epub 2007 Nov 16. Review. PMID: 18008087

Robinson SN, van Os RP. Mobilization of hematopoietic stem and progenitor cells in mice. Methods Mol Biol. 2008;430:31-53. PMID: 18370290

2007:

Wiersema A, Dijk F, Dontje B, van der Want JJ, de Haan G. Cerebellar heterokaryon formation increases with age and after irradiation. Stem Cell Res. 2007 Nov;1(2):150-4. Epub 2008 Mar 4. PMID: 19383395

Alberts R, Terpstra P, Hardonk M, Bystrykh LV, de Haan G, Breitling R, Nap JP, Jansen RC. A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, human and rat. BMC Bioinformatics. 2007 Apr 20;8:132. PMID: 17448222

De Haan G, Gerrits A. Epigenetic control of hematopoietic stem cell aging, the case of Ezh2. Ann N Y Acad Sci. 2007 Jun;1106:233-9. Epub 2007 Mar 1. Review. PMID: 17332078

Yeoh JS, Ausema A, Wierenga P, de Haan G, van Os R. Mobilized peripheral blood stem cells provide rapid reconstitution but impaired long-term engraftment in a mouse model. Bone Marrow Transplant. 2007 Apr;39(7):401-9. Epub 2007 Feb 12. PMID: 17293881

De Haan G. Latexin is a newly discovered regulator of hematopoietic stem cells. Nat Genet. 2007 Feb;39(2):141-2. No abstract available. PMID: 17262023

Van Os R, Kamminga LM, Ausema A, Bystrykh LV, Draijer DP, van Pelt K, Dontje B, de Haan G. A limited role for p21cip1/waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells. 2007 Apr;25(4):836-43. Epub 2006 Dec 14. PMID: 17170062

Yeoh JS, de Haan G. Fibroblast growth factors as regulators of stem cell self-renewal and aging. Mech Ageing Dev. 2007 Jan;128(1):17-24. Epub 2006 Nov 21. Review. PMID: 17118424

2006:

Wierenga PK, Weersing E, Dontje B, de Haan G, van Os R. Differential role for very late antigen-5 in mobilization and homing of hematopoietic stem cells. Bone Marrow Transplant. 2006 Dec;38(12):789-97. Epub 2006 Nov 6. PMID: 17086206

Rizo A, Vellenga E, de Haan G, Schuringa JJ. Signaling pathways in self-renewing hematopoietic and leukemic stem cells: Do all stem cells need a niche? Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R210-9. Review. PMID: 16987886

De Haan G, Gerrits A, Bystrykh L. Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells. Curr Opin Hematol. 2006 Jul;13(4):249-53. Review. PMID: 16755221

Peeters SD, van der Kolk DM, de Haan G, Bystrykh L, Kuipers F, de Vries EG, Vellenga E. Selective expression of cholesterol metabolism genes in normal CD34+CD38- cells with a heterogeneous expression pattern in AML cells. Exp Hematol. 2006 May;34(5):622-30. PMID: 16647568

Yeoh JS, van Os R, Weersing E, Ausema A, Dontje B, Vellenga E, de Haan G. Fibroblast growth factor-1 and -2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures. Stem Cells. 2006 Jun;24(6):1564-72. Epub 2006 Mar 9. PMID: 16527900

Kamminga LM, de Haan G. Cellular memory and hematopoietic stem cell aging. Stem Cells. 2006 May;24(5):1143-9. Epub 2006 Feb 2. Review. PMID: 16456126

Van Pel M, van Os R, Velders GA, Hagoort H, Heegaard PM, Lindley IJ, Willemze R, Fibbe WE. Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1469-74. Epub 2006 Jan 23. PMID: 16432201

Van Os R, Ausema A, Noach EJ, van Pelt K, Dontje BJ, Vellenga E, de Haan G. Identification of quantitative trait loci regulating haematopoietic parameters in B6AKRF2 mice. Br J Haematol. 2006 Jan;132(1):80-90. PMID: 16371023

Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, Dontje B, de Haan G. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood. 2006 Mar 1;107(5):2170-9. Epub 2005 Nov 17. PMID: 16293602

Lombaert IM, Wierenga PK, Kok T, Kampinga HH, de Haan G, Coppes RP. Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin Cancer Res. 2006 Mar 15;12(6):1804-12. PMID: 16551865

2005:

Alberts R, Terpstra P, Bystrykh LV, de Haan G, Jansen RC. A statistical multi-probe model for analyzing cis- and trans-genes in genetical genomics experiments with short-oligonucleotide arrays. Genetics. 2005 Nov;171(3):1437-9. Epub 2005 Aug 3. PMID: 16079228

Bystrykh, L. V., Weersing, E., Dontje, B., Sutton, S., Pletcher, M. T., Wiltshire, T., Su, A. I., Vellenga, E., Wang, J., Manly, K. F., Lu, L., Chesler, E. J., Alberts, R., Jansen, R. C., Williams, R. W., Cooke, M., and de Haan, G. Uncovering regulatory pathways affecting hematopoietic stem cell function using ‘genetical genomics’. Nat Genet. 2005 Mar;37(3):225-32. Epub 2005 Feb 13. PMID: 15711547

De Haan, G. A novel growth factor encoded by an old gene. Haematologica. 2005 Feb;90(2):152. No abstract available. PMID: 15710563

Van Pelt K, de Haan G, Vellenga E, Daenen SM. Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells. Exp Hematol. 2005 Feb;33(2):226-31. PMID: 15676217

Kamminga LM, van Os R, Ausema A, Noach EJK, Weersing E, Dontje B, Vellenga E, de Haan G. Impaired Hematopoietic Stem Cell Functioning After Serial Transplantation and During Normal Aging. Stem Cells. 2005;23(1):82-92. PMID: 15625125

De Haan, G, Williams RW. A genetic and genomic approach to identify longevity genes in mice. Mech Ageing Dev. 2005 Jan;126(1):133-8. Review. PMID: 15610771

Roeder I, Kamminga LM, Braesel K, Dontje B, De Haan G, Loeffler M. Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization. Blood. 2005 Jan 15;105(2):609-16. Epub 2004 Sep 16. PMID: 15374890

Selected publications <2005:

Van Os R, Kamminga LM, de Haan G. Stem cell assays: something old, something new, something borrowed. Stem Cells. 2004;22(7):1181-90. Review. PMID: 15579638

Van Os R, de Haan G. The balance among immune suppression, stem cell ablation, competition, and engraftment. Blood. 2004 Apr 1;103(7):2859; author reply 2859-60. No abstract available. PMID: 15033883

Van Zant G, de Haan G. Genetic control of lifespan: studies from animal models. Expert Rev Mol Med. 1999 Dec 28;1999:1-12. PMID: 14585117

De Haan G, Weersing E, Dontje B, van Os R, Bystrykh LV, Vellenga E, Miller G. In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1. Dev Cell. 2003 Feb;4(2):241-51. PMID: 12586067

De Haan G, Bystrykh LV, Weersing E, Dontje B, Geiger H, Ivanova N, Lemischka IR, Vellenga E, Van Zant G. A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood. 2002 Sep 15;100(6):2056-62. PMID: 12200366

De Haan G. Hematopoietic stem cells: self-renewing or aging? Cells Tissues Organs. 2002;171(1):27-37. Review. PMID: 12021489

Geiger H, True JM, de Haan G, Van Zant G. Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy. Blood. 2001 Nov 15;98(10):2966-72. PMID: 11698278

Kamminga LM, Akkerman I, Weersing E, Ausema A, Dontje B, Van Zant G,de Haan G. Autonomous behavior of hematopoietic stem cells. Exp Hematol. 2000 Dec;28(12):1451-9. PMID: 11146167